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If one employs bulky phosphonium ions such as [Cy3PH]+ and [Mes3PH]+, the resulting phosphine does not coordinate to the generated cation which then leads to a productive catalytic system [109].
However, although these benzoic acid derivatives each contain a negatively charged carboxylate 'warhead' intended to coordinate to the active site zinc ion, the 2.25 Å resolution X-ray crystal structure of LpxC complexed with 3- heptyloxy benzoate reveals 'backward' binding in the hydrophobic tunnel, such that the benzoate moiety does not coordinate to zinc.
While the 2,6-pydc ligand in compound 1 uses both its carboxylate groups for coordination to nickel II), the 2,3-pydc ligand in compound 2 binds through only one of the carboxylate groups, and the second carboxylate group which is expected to bind to another Ni II) atom, does not coordinate to the metal.
The crystal structure of the product revealed that the bipy moiety does not coordinate to the Sn atom, but forms a cyclic tetrameric adduct of formula [Ph3SnL1H(H2O)]2 · bipy2 through hydrogen bonding between the water ligand of Ph3SnL1H(H2O) and the bipy N atoms.
The equivalent position in IsdA-N1 is taken by a His, which is a common iron ligand but does not coordinate to the heme-iron in the crystal structure(10) or in solution in the absence of a strong reductant.
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The oxazoline ring in 3 and 6 did not coordinate to the metal center.
2 and 3 are isostructural, in which solvent molecules, DMA and NMP, do not coordinate to zinc ions, and 1D double stranded chain structures are formed.
SCN–, Cl–, HCOO–, and SO42– are also competitive inhibitors, although they do not coordinate to Fe.
16c In the chiral tetramer A, six iPr2Zn moieties coordinate to the nitrogen atoms that do not coordinate to the Zn2O2 square.
The apocarotenoid substrate does not coordinate directly to the metal, and leaves one metal coordination site occupied by a water molecule in the enzyme substrate complex.
At the strategic level, we show that if the retailer does not coordinate its logistics and marketing efforts to improve the overall returns system, then it will tend to over-invest in one of the functions and under-invest in the other.
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