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We then wanted to know whether the expression of a localized anti-GFP DARPin can be used to re-localize a functional GFP fusion protein.
Mitochondria are highly motile organelles, which possess the capability to re-localize to subcellular regions of a cell depending on local energy demands.
Ago2 is known to re-localize to cytoplasmic granules under stress [19].
Thus, we decided to tag p53 with IC and check its ability to re-localize and recruit the SV40 TAg to muNS-related cytoplasmic inclusions.
In these studies, MSH2 and MSH6 were found to re-localize to sites of damage after exogenous insult [16], [17], [18], [19].
Moreover, SK2 was found to re-localize to nsP3-G3BP1-positive foci.
Therefore, we aimed to re-localize the enzymes of valine biosynthesis from the mitochondrial matrix into the cytosol.
We have shown that TTFields disrupt the ability of septins to re-localize to the cytokinetic furrow and reduce the accumulation of F-actin [ 3].
On the other hand, 3G61-mRuby2 (Fig. 2F) and 3G146-mRuby2 (Fig. 2G) failed to re-localize to the plasma membrane.
For some of these events to occur, proteins must re-localize from one sub-cellular compartment to another to gain access to their substrates or interacting partners.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com