Two well documented limitations to the strengthening technology though are premature FRP debonding failure and non-ductile member behaviour.
Some of the well documented limitations are missing data, abstraction errors and misclassification errors [ 10].
This should erode the previously documented limitations of detection although in the background of the cirrhosis, there still are significant limitations in detection.
Importantly, standardized serological tests are widely available only for the diagnosis of B. ovis infection [ 19], although serology has well documented limitations in these cases [ 19, 20].
This short, direct test of various cognitive domains has been used in seminal dementia studies but has a number of well documented limitations [ 15].
However, despite documented limitations [ 14], there has been increased recognition of the role of systematic reviews of qualitative research in developing an evidence base for care [ 15].
However, there have been several documented limitations regarding the accuracy and precision of these devices, including greater differences compared with a standard plasma-based methodology as INRs increase above the therapeutic range [ 4– 7].
For example, there are documented limitations in NMES efficacy in patients with obesity and peripheral limb edema [ 3], and one study demonstrated treatment failures in 50% of patients, even in a non-obese cohort [ 4].
The consideration here is mainly based on the well documented limitations of using established cell lines to predict a clinical response, with several compounds that show dramatic tumor killing in cell models failing to yield clinical benefits.
This will rely heavily upon the ability to obtain viable tumour material and also to overcome previously documented limitations in generating high-quality chromosome preparations from biopsied tumour tissue (e.g. Carter et al, 1990; Hahn et al, 1994 and others).
