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Only one gene, UGT1A8, had dual promoter expression that was specific to liver and kidney, which contradicts the published literature reporting only extra-hepatic expression, but is consistent with the recent publication of Li et al. [24], which documents expression in the liver.
Data for genes upregulated after pathogen exposure were taken directly from the study by Engelmann et al. [ 28], which documents expression profiles after three different bacterial infections and two different fungal exposures.
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Previous reports document expression of low-density lipoprotein receptor-related protein 5 (LRP5) in osteosarcoma (OS) tissue.
The previously documented expression of Tbx18 in epicardial cells as well as epicardial progenitors [2], also validates the epicardial identity of our signature gene collection.
The general stress response following these processes is moreover in agreement with the well documented expression of immediate early genes [55].
Identified transcription factors were confirmed to have previously documented expression in mammalian liver by consulting the Human Protein Reference Database [40] (http://www.hprd.org) and PubMed (http://www.pubmed.org).org
We focused on transcription factors with previously documented expression in liver (the site of Lp(a) production) and identified 7 SNPs for which genetic variation is likely to influence binding of such transcription factors (Figure 5).
JS constructed the recombinant adenovirus and documented expression of αT2ib.
In addition to documenting expression of Notch pathway components, several studies have examined pathway activation.
At least 10 guts were analyzed from each line to document expression.
ABL1 was chosen as the endogenous control based on its documented expression and stability in leukemia samples.
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