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We note that the ECHA guidance documents benefit from updates and that a series of fact sheets is available.
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There is also no documented benefit of the two-incision route.
Although several small single center studies have suggested MIS technologies decrease surgical morbidity and reduce hospital stay, evidence documenting benefit from a patient perspective remains limited.
When looking at opioids, the guideline asserts that only studies documenting benefit for over a year were worthy of inclusion.
There has been no documented benefit to public safety in Texas as Governor Abbott pledged, but some police departments have taken note instead of a disturbing decrease in crime reporting by Latinos.
Other liver-related complications (portal hypertension, esophageal varices, ascites, hepatic encephalopathy) are treated with the same modalities as used in cirrhosis, although the use of transjugular intrahepatic portosystemic shunt treatment is discouraged due to the lack of documented benefit.
[ 11] Although the delivery of primary care has documented benefit, health services use by patients with schizophrenia is frequently suboptimal.
Raloxifene has a documented benefit to reduce the risk of vertebral but not of non-vertebral or hip fracture risk.
Molecular tests such as GGI are promising in terms of clinical benefit, but so far the documented benefit is complementary to histopathological methods [ 32].
Thus, the lack of documented benefit of PAC use in these clinical trials probably more reflects inadequate study design than inadequate utility [ 32].
For the moment, there will be continued reliance on structural outcomes of OCT and MRI to document benefit on reducing neuronal and axonal degeneration or improving tissue repair.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com