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However, in order to be a viable measure of treatment outcome in clinical trials, Patient-Reported Outcomes (PRO) instruments must be extensively documented to both meet scientific standards [ 6] and to satisfy regulatory criteria, particularly from the perspective of claims for labeling and promotion [ 7].
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For example, an antibody raised against a H3K79me3 antigen that is documented to recognize both H3K79me3 and H3K79me2, detects both H3K79me3 and H3K79me2 peptides when tested on HEMP slides (Fig. 2b).
Exploring otherwise hidden information within intervals-in-time, heart rate variability (HRV) has been documented to be both altered in the presence of sepsis, and correlated with its severity.
Using these techniques, heart rate variability (HRV) has been documented to be both altered in the presence of systemic infection, and correlated with its severity.
SM proteins have been documented to be both positive and negative regulators of fusion, and studies of overexpression of SM proteins have produced conflicting observations [ 17- 20].
Interestingly, a number of naturally occurring ligands (glucagon and oxyntomodulin) have been documented to activate both the glucagon receptors and the GLP-1 receptor (Jorgensen et al., 2007).
Since aristolochic acid (AA) has been documented to be both nephrotoxic and carcinogenic [ 9, 10], AA-containing CHPs (Chinese herbal products) were banned in November 2003 in Taiwan.
Perioperative haemodynamic optimisation of high-risk surgical patients has long been documented to improve both short-term and long-term outcomes, as well as to reduce the rate of postoperative complications.
Protease inhibitors (PIs) used as components of highly active antiretroviral therapy (HAART) have been well documented to reduce both the morbidity and mortality associated with HIV infection [ 1, 2].
There is clear reproductive isolation between the various species, with imprinting documented to occur both on songs and on beak shape (incidentally, the shape of the beak has by itself a strong influence on the song).
In mouse models of sepsis and endotoxemia, MMPs have been documented to have both protective effects and damaging effects depending on the MMP, the route and type of infection (Vanlaere & Libert, 2009).
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