The former assumption is bolstered by the lack of documented thresholds in both cohort [ 25, 26] and time-series mortality [ 27, 28] investigations.
A score of 2 was allocated to those patients with both elevated CRP (>10 mg l−1) and hypoalbuminaemia (<35 g−1), those with only an elevated CRP (>10 mg l−1) were allocated a score of 1, whereas those with normal CRP (⩽10 mg l−1) were allocated a score of 0. The NLR ratio was constructed using previously documented thresholds (Guthrie et al, 2013).
Briefly, patients with both an elevated C-reactive protein (>10 mg l−1) and low albumin (<35 g l−1) were allocated a score of 2; patients in whom only C-reactive protein was elevated (>10 mg l−1) were allocated a score of 1; and patients with a normal C-reactive protein were allocated a score of 0. The NLR ratio was constructed using previously documented thresholds (Guthrie GJ et al, 2013a).
As has been documented, different threshold choices can lead to different results from enrichment analysis, and thus different biological conclusions [ 22].
For each sample, results were documented as cycle threshold (threshold set to 100 relative fluorescence units) values of background subtracted qPCR fluorescence kinetics by using the MX Pro Stratagene analysis software, applying the adaptive baseline, amplification based threshold, and moving average algorithm enhancement.
The effective dose for chemical water treatments to control plant pathogens was in some cases above documented phytotoxicity thresholds, and for most crops and technologies the phytotoxicity thresholds remain unknown.
We chose thresholds that were close to genome-wide levels of significance and previously documented EWAS FDR threshold (Patel et al., 2010).
Further inspection of the "normal" visual field documented with Full Threshold algorithm however suggests a borderline visual field defect suggestive of VGB toxicity.
SITA standard correctly identified all patients with VGB attributed field loss documented on Full Threshold as having VGB attributed field loss on SITA standard suggesting a false negative rate of 0%.
One patient was falsely diagnosed as having VGB attributed visual field loss with both SITA algorithms when there was none documented on Full Threshold (1/10 = 10%) suggesting that the false positive rate was 10% for both SITA algorithms.
