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We have documented solid phenotypes involving social and motor behaviour, skull and brain morphology, and brain histology, and have linked them to subsets of genes in the Wbscr.
For study entry, patients were required to have a histologically or cytologically documented solid malignancy refractory to standard treatment, could not receive standard treatment or standard treatment was not available and were not previously treated with cisplatin or carboplatin.
Eligible patients (aged > 18 years) had histologically or cytologically documented solid tumors, had an Eastern Cooperative Oncology Group performance status ≤ 2, and were candidates for treatment with erlotinib or with the combination of gemcitabine and erlotinib in the opinion of the investigator.
Eligible patients with histologically or cytologically documented solid tumours or lymphoma were enroled in three sequential, dose-escalating cohorts to receive motesanib 50 mg once daily (QD), 75 mg two times daily (BID), or 125 mg QD in combination with gemcitabine (1000 mg m−2).
Eligible adult (⩾18 years) patients had histologically or cytologically documented solid tumours or lymphoma; Eastern Cooperative Oncology Group score zero to two; systolic/diastolic blood pressure ⩽145/⩽85 mmHg; adequate cardiac, hepatic, and renal function; and were candidates for gemcitabine treatment as deemed by the investigator.
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Computerised tomography scanning documented a solid mass (7 × 6 cm diameters) infiltrating the ileum and reaching the abdominal wall.
Patients were required to have histologically or cytologically documented advanced solid tumours refractory to conventional therapy or for whom there are no standard therapies.
Patients were eligible if they had histologically or cytologically documented advanced solid malignancy, refractory to standard therapy or for which conventional therapy was not effective.
IDH gene mutations have been documented in solid tumors and de novo AML (Chou et al. 2010; Yan et al. 2009).
Consistent with these preclinical data, bortezomib has been effective in clinical trials for myeloma (Richardson et al, 2003, 2005; Jagannath et al, 2004) and responses have been documented in solid tumours, including renal cancer (Kondagunta et al, 2004), small cell and non-small cell lung cancer (Lara et al, 2006a, 2006b), and prostate cancer (Hainsworth et al, 2007).
The approach documented here implements solid species thermodynamic functions derived from the enthalpies and entropies of reactions including oxidation/reduction and additional point defect reactions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com