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Domestic cattle have been under quite strong, recent and well documented selection for several traits and hence their genomes should contain evidence of this selection.
Most studies had clear objectives, documented selection criteria, provided a representative sample, defined the exposure/characteristics of participants under study and used appropriate statistical tests.
Such a sampling is more often done implicitly, based on the perceived importance of projects from a financial or strategic point of view, than explicitly, i.e. with a list of the entire portfolio to which one applies documented selection criteria.
Several of the genes that we identified here confirm previously documented selection signatures in Holstein cattle populations, such as ACTC1 [ 9], FABP3 [ 34], RORA [ 34], GHR [ 34] and LACTB [ 34].
Our experience using HRM and TaqMan PCR in routine shows that reporting delays suitable with the oncologist expectation could be achieved and enable rational, fully documented, selection of first-line therapy in mCRC.
In the particular case of responses to climate change, it is important to mention that many studies have documented selection favouring earlier breeding pairs before climate change was a recognized issue (Perrins 1965; Lack 1968; Price et al. 1988).
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Studies did well on a number of quality assessment questions including having clear objectives, documenting selection criteria, providing a representative sample, defining interventions/characteristics under study, defining and using appropriate outcomes, describing results clearly and using appropriate statistical tests.
The studies in general did well on a number of quality assessment questions including having clear objectives, documenting selection criteria, providing a representative sample, defining interventions/characteristics under study, defining and using appropriate outcomes, describing results clearly and using appropriate statistical tests (where described).
Prior to the construction of the CHEMDNER corpus, we encountered a range of problems with previous studies, related to corpus availability, lack of proper documentation, lack of document selection criteria, not enough information on annotation guidelines or problems with the corpus format.
Drotz et al. [27] documented that selection acted on α-Glycerophosphate dehydrogenase (α-Gpdh) in A. bipustulatus between the valley floor and above the tree line in Scandinavia.
We documented strong selection on response to environmental stimuli in both populations.
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