Strong p27 expression, a documented marker of mPIN in MPAKT mice [37], was observed in mPIN of the vehicle-treated and RAD001-resistant MPAKT mice, but absent in WT animals and in the reverted lesions of RAD001-sensitive mice, providing additional evidence for RAD001-resistance (Fig. 7).
Based on the documented marker stability (mean error of rigid body fitting) and marker scatter (condition number), 2 standard deviations of error for the motion parameters studied (proximal-distal translations and abduction-adduction) would most probably amount to 0.25 mm and 1 degree or less respectively.
Most importantly, research has indicated that behavioral inhibition can be detected at a fairly young age, with some studies even documenting markers of this temperament factor in children as young as 4 months [ 30].
Researchers who have conducted manual content analyses have also documented linguistic markers of deception [30]; for example, perpetrators of homicide or kidnapping may use past tense (vs. present or future) when discussing the victim, and deceivers may try to distance themselves from the crime by using "they" rather than "I" in statements [4].
Several documented dendritic markers, including homer-GFP, Apc2-GFP, Act5C-GFP, Nod- β -gal and Rdl-HA [43], [44], were ectopically expressed in the larval MBs using GAL4-201Y as the driver.
We have also documented increased markers of endothelial activation (i.e., sE-selectin and sICAM-1) in subjects with higher anxiety.
Whereas measurement of plasma viraemia ('viral load') and CD4 T cell count are documented surrogate markers of HIV clinical progression, the clinical relevance and utility of measuring the reservoir regardless of assay remains less clear.
In this regard, investigations performed in the USA documented that markers of sociodemographic disadvantage including black ethnicity associate with less frequent use and later initiation of synthetic and biologic DMARD as well as more regular NSAID use [ 78– 80].
Our observations of impaired post-load glucose tolerance and increased risk of GDM among women who snore during pregnancy are also consistent with a growing body of epidemiological evidence that documents markers of the severity of obstructive sleep apnea (OSA) and increased risk of type 2 diabetes in diverse populations of men and non-pregnant women from various geographic regions [ 32, 36- 38].
