The role of surface loops in Pla proteolysis has earlier been documented by loop swapping [ 16, 26], and our results extend these findings by a more detailed substitutional analysis and by also conferring invasiveness onto a close ortholog of Pla.
The ISSUE 3 study led to reappraisal of pacing therapy (using DDD pacing with the rate-drop response algorithm) for reducing syncope recurrence in a highly selected patient group (age, ≥40 years) with asystolic VVS clinically documented by implantable loop recorder.
We speculate that this increase is due to an initial activation of integrin α5β1, as observed in vitro, followed by an increase in cell surface level, a positive feedback control loop previously documented for integrins in many other systems [42], [43].
We documented that automated closed-loop glucose control, based on continuous subcutaneous glucose levels, is feasible and may significantly improve glucose levels without increasing the risk of hypoglycemia in critically ill adults.
Yet, according to stakeholders, poor adherence to the documented MOH policy coupled with loop holes in the regulations that restricts the entry of CAM products through other venues, significantly eroded the effectiveness of current regulation.
She underwent implantation of a cardiac loop recorder, which documented three episodes of asystole longer than 3 s over a period of 4 months: a cardiac pacemaker was implanted.
The ride that had already taken him on his well-documented loop-the-loop from the mean streets of Leeds via wild years at Wigan to born-again Christianity is still charging along.
This provides an overview of the landscape of relevant positive feedback loops occurring in documented reaction networks.
Such feedback loops have been well documented in birds, mice, cats and rhesus monkeys.
The major rule to annotate miRNA in plants is whether precise excision of approximately 21-nt miRNA/miRNA* duplex from qualifying stem-loop can be well documented [14].
