Sentence examples for documented in stage from inspiring English sources

Once safety and effectiveness have been documented in stage IV disease, treatment modalities should be moved rapidly into randomized and non-randomized neoadjuvant trials to confirm clinical effectiveness and to elucidate pathologic and molecular responses.

Whereas growth rates were similar, a small increase in MT nucleation corrected for average rescue frequency was documented in stage 3 extracts, but whether this is relevant to nucleation in the spindle is unclear.

Durable clinical responses have been recently documented in stage IV melanoma patients infused with polyclonal anti-tumor PBMCs, pre-stimulated in vitro with the autologous tumor cells, and given in combination with low-dose IFN-α [ 41].

Complete response was documented in one stage 4 patient, partial response in 12 (two stage 3, 10 stage 4), mixed or no response in 25 (ten stage 3, 15 stage 4) and disease progression in five (one stage 3, four stage 4) Twenty-four patients (12/13 stage 3, 12/30 stage 4) are alive at 22 153 months (median, 59) from diagnosis.

Integrating these novel findings on the physiological changes that occur in early-stage WNS with those previously documented in late-stage infections, we propose a multi-stage disease progression model that mechanistically describes the pathologic and physiologic effects underlying mortality of WNS in hibernating bats.

The play's estrangement techniques, which are documented in its stage directions, Joyce's preparatory notes, and Richard's speculative ethical experiments, demonstrate this other dimension of Ibsenite affinity.

Thus, the early features of sympathetic affection and brainstem locus coeruleus pathology typically documented in early stage sporadic PD were not observed in our Pink1−/− mice, suggesting that the effect of PINK1 deficiency in mouse does not reach this stage or has different tissue specificity.

Stage 1 cancer was documented in 22 patients, stage 2 in two patients, stage 3 in five patients and stage 4 cancer in eight patients.

External suture obliteration was documented in three stages.

Similar phenomena have been documented in early-stage breast cancer, lung cancer and melanoma.

Increased IL-6 serum levels have also been documented in high-stage CLL by Fayad et al. [ 34].