We selected RANTES for further studies because it was the highest upregulated cytokine in VMR-CM and its documented implication in tumor progression [25], [26].
The given findings from the above negative control experiment, in relation to the documented implication in pancreas development of the murine Wnt5a and the zebrafish Wnt5b [ 3, 5], both carrying this cluster of TFBS, further support the functionality of this conserved regulatory module.
This is a "bottom up" approach, focused on understanding and working with the problem on a very local level, and scaling up to promote a more global sphere of influence by learning from this approach, and identifying and documenting implications for either policy or practice transfer to other locations.
However gaps between guideline development and implementation are well documented, with implications for health care quality, safety and effectiveness.
Although NT-3 has been recently shown to be involved in cardiovascular diseases [21], the present data fail to document its implication in SSc The present results confirmed previous reports [13], [14], [22] that circulating levels of NGF are increased in SSc.
More recently, an implication of T-type calcium channel in the processing of Amyloid Precursor Protein was documented, with possible implication in the pathogenesis of Alzheimer's disease.
To document the implications of trade policies on agricultural performance, we explore here various outcomes, including the volume of exports and the share of Argentine agricultural production on world production, an index of agricultural production, and the performance of yields in Argentine agriculture (vis-á-vis the US).
It would have been useful for Paciorek and Liu (2009) to document the implications of the spatial temporal resolutions and aggregation of AOD and PM2.5 (data they used) on their findings.
Here, we investigated infant growth trajectories and traits indicative of childhood obesity using the UK-WHO charts, with the aim to clearly document the implications of adopting the new charts on UK growth monitoring practice.
For instance, the anterior temporal pole was not modulated by the semantic relationship between items despite the well-documented implication of this region in conceptual knowledge [ Hodgeset al., 1992; Kensinger et al., 2003].
Nonetheless, the importance of attractor dynamics in cortical activity is well documented, with significant implications for the brain at rest and while performing tasks [7 10].
