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These properties are discussed considering the documented function of class III glutaredoxins in development.
Among the transcription factors (TFs) with a documented function in somatic cell reprogramming23, the proto-oncogene MYC has a pivotal role in growth control, differentiation, and apoptosis and its expression level is tightly regulated in physiological conditions24.
The best documented function of VHL protein (pVHL) relates to its ability to target the hypoxia‐inducible transcription factor (HIF) for polyubiquitylation and proteasomal degradation.
The best documented function of the VHL gene product, pVHL, relates to its role as the substrate recognition module of an ubiquitin ligase complex that targets the α-subunit of hypoxia-inducible factor (HIF) for destruction in the proteasome.
ALKBH6 has no documented function.
Phylogenetic trees were inspected for evident branches supported by bootstrap analysis and for proteins of documented function as described above.
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NRF2 has many other documented functions.
An attractive alternative is to develop peptides from endogenous mitochondrial-localized proteins with documented functions.
tra is crucial for normal female somatic sex determination and behavior, again with no documented functions in males.
The majority of miRNAs regulated in this study have documented functions within the immune system (see Table 4).
The documented functions and expression patterns of MK2 and MK3 overlap, but MK2 is expressed at significantly higher levels, and assumed to be the dominant isoform.
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