Sentence examples for documented essential from inspiring English sources

This observation is consistent with the documented essential role of NANOG and OCT4 in the maintenance of the pluripotent state and the restriction of their functions to ESCs.

We thus focused on homozygote mutants, with the expectation that partial rescue from ttnb could potentially elicit phenotypic differences among mutants, especially in skeletal muscle where it is expressed at comparable levels to ttna and has a documented essential role.

Our detailed investigation of clinical signs, seroconversion, histopathologic lesions, and various viral parameters allowed us to document essential data on the course and clinical outcome of ABV infections and on the similarities and differences between ABV and BDV infections.

Previous studies have documented the essential roles of TrkA receptor in neural development, and genetic deletion of TrkA severely impairs establishment of the sympathetic system (Smeyne et al., 1994).

Moreover, several studies in higher eukaryotic systems documented the essential role of sirtuins for maintenance of autophagy during conditions of nutrient starvation [58], [59].

Recent studies have documented an essential role for various miRNAs in modulating key components of the hypertrophic process in the heart [6] [13].

Peptides are synthesized from antigens that (i) have a documented and essential role in parasite development, (ii) have secondary structure motifs suggesting surface exposition, (iii) have conserved sequence stretches, and (iv) induce parasite-inhibitory antibodies.

Furthermore, PUUV antigen has been found in cardiac tissue (6), and other studies have documented the essential role of coagulopathy in HFRS disease severity (13– 13).

The enzyme aurora B kinase, which is part of the chromosome passenger complex, and the protein kinase BUB1 have through recent studies been documented as essential for accurate chromosome inheritance at mitosis.

It was said that documents essential to the case, which should have been disclosed to the defence, had been destroyed.

A more knowledgeable exploration of documents essential to American history took place on Independence Day in the area of Central Park known as Strawberry Fields.