Sentence examples for documented defects from inspiring English sources
Interestingly, the cell lines which can maintain higher levels of DEDs, such as COS-7, also have documented defects in p53 signaling.
Lopez-Jornet and Camacho-Alonso have documented defects in teeth and periodontium after only 6 months in situ [ 42].
They documented defects of the 5A3del hematopoietic stem cell (HSC) KLS-CD150hi cells, which were relatively increased in mutant mice as compared with WT mice.
In spite of the massive lymphadenopathy and documented defects in activated T-cell apoptosis in Bim-deficient lpr mice, it remains uncertain which cell type is the most critical determinant triggering exacerbated autoimmunity in these mice.
Besides the presynaptic and postsynaptic abnormalities discussed in the previous sections, a few cell-based studies have documented defects in neuronal differentiation, specifically in neurite outgrowth and dendrite spine formation.
Furthermore, previous reports have documented defects in small G-protein targeting after statin treatment (Laezza et al, 1998; Kusama et al, 2001; Holstein et al, 2002; Ghittoni et al, 2005; Walker and Olson, 2005).
In leukaemic blasts with a documented defect in MTX uptake, F-MTX accumulation was abolished in almost all the cells.
There was no significant intracellular F-MTX accumulation over this period in a K562 subline (K500E) with a documented defect (approximately 10% of wild type) in membrane transport by the reduced folate carrier (RFC).
In addition to activity during early embryogenesis, there are targets (the same or different) that continue to be relevant to organ development at later stages, and we documented specific defects in cardiovascular morphology induced between 24 48 hpf.
Small-molecule signal-transduction inhibitors (STIs) with oral bioavailability have demonstrated single-agent clinical activity in tumours with documented molecular defects in dominant biochemical pathways.
Since Aldh1b1 is expressed only in pancreatic progenitors and briefly in newly formed fetal beta cells, the origin of the documented islet defects is embryonic.
