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In this survey, aiming at analysing data on PLD use in breast cancer treatment in a "real life" setting, PLD doses and their modification were documented cycle by cycle.
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Dose reductions were adopted in 15% of the documented cycles and were mainly related to capecitabine.
For reefs where we were able to document cycles of disturbance and recovery, a high percentage (92%) either did not decline or declined and recovered.
Responses were documented after cycle 2 in three cases and cycle 4 in one case.
Toxicity was documented every cycle.
Toxicity documented every cycle was generally mild (Table 2-wrap>).
A complete MRD clearing was documented after cycle 3 and maintained in all subsequent evaluations.
For each sample, results were documented as cycle threshold (CT) set to 100 relative fluorescence unit values of background subtracted qPCR fluorescence kinetics by using the MX Pro Stratagene analysis software, applying the adaptive baseline, amplification based threshold and moving average algorithm enhancement.
For each sample, results were documented as cycle threshold (threshold set to 100 relative fluorescence units) values of background subtracted qPCR fluorescence kinetics by using the MX Pro Stratagene analysis software, applying the adaptive baseline, amplification based threshold, and moving average algorithm enhancement.
Of the 73 articles, 47 documented PDSA cycles in sufficient detail for full analysis against the whole framework.
As this study represents a re-evaluation of cell cycle-regulated gene expression and was not influenced by expectations from the literature, it was reassuring that it identified and confirmed so many previously documented cell cycle-regulated factors.
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