By creating a method for systematically documenting amendments, and for recording decisions on the significance of these amendments, we intended to provide a body of information that trialists could use to make an informed decision.
However, in these cases, the changes to the study protocol should be documented in amendments of the original study protocol.
Some legislators have promised to keep God in the Constitution if they can simply rewrite the document amendment by amendment -- an exercise that could take years.
41 Any modifications to the intervention protocol will be submitted for approval to the investigating team with amendments documented using version control.
In 30 of these (58%, 43% to 71%) study methods were changed, as documented in the amendments submitted to the research ethics committee.
Therefore, our strategy for managing them was to document every amendment, seek the approval of the relevant ethics committees for these changes, have independent external researchers provide project oversight, and have an independent external party audit the whole trial after it was completed, including adherence to the protocol.
Sodium carbonate amendment documented marked improvement in power yields due to improvement in the system buffering capacity.
It is clear and well documented that Fourth Amendment exceptions based on drug violations have contributed to precedent balanced heavily in favor of law enforcement over civil liberties.
interclick's stockholders are advised to read these documents, any amendments to these documents and any other documents relating to the tender offer that are filed with the SEC carefully and in their entirety prior to making any decisions with respect to the offer because they contain important information, including the terms and conditions of the offer.
Minor administrative amendments are documented in notes to file.
Any planned or actual changes from the original written protocol in the conduct should be documented with formal protocol amendments.
