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Under pathological conditions such as tumor growth and graft-versus-host disease, the documented accumulation of MDSCs in patients and mice suggested a critical contribution of MDSCs to these immunosuppressive conditions (Almand et al., 2001).
Kashiwagi et al.[ 29] documented accumulation of Cd in shoots of field-grown rice prior to and following heading.
The documented accumulation of acidic intracellular compartments is supportive of an affiliation with the media pH shift, by either contributing directly to the environmental acidification, or rather resulting from it, as seen in breast cancer cells (Glunde et al, 2003).
In those experiments, animals fed with enriched AGE diets had an increased immunochemically documented accumulation of AGEs in ovarian tissue and elevated serum levels and this was associated with an impaired hormonal and metabolic profile expressed as elevated insulin and androgen levels, compared to animals fed a low AGE-content diet.
Documented accumulation of antimicrobials in worms and plant material and subsequent uptake by higher organisms is a known pathway for ecological risks from exposure of vertebrae, including songbirds.
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The combination of enthusiastically documented personal accumulation and an unworried tilt in cadence is what makes Ross Ross.
In addition to providing a mechanistic basis for the recognized deficiencies in NO/cGMP signaling associated with Alzheimer's disease pathogenesis, our data may have implications for peripheral vascular disease in light of the documented Aβ accumulation in diseased peripheral as well as cerebral blood vessels.
Several studies have documented the accumulation of splenic MDSCs, displaying variable intensity of the Gr-1 marker in various tumor models (17, 19, 31, 32).
We have also documented an accumulation of SNPs causing functional alterations within this region, as would be expected for a genomic region suffering both the deleterious effects of Muller's Ratchet and accumulation of deleterious alleles hitchhiking to fixation with advantageous alleles.
Sequence analysis of three longitudinally sampled S. aureus ST30 isolates collected from a single patient with cystic fibrosis over a 26-month period documented the accumulation of 23 SNPs and 15 insertions/deletions (InDels), mainly in genes involved in virulence, global regulation, metabolism, and antibiotic resistance (McAdam et al. 2011).
It has been documented that accumulation of amyloid β-peptide (Aβ), which is a cleavage form of β-site amyloid precursor protein (β-APP), acts as a fundamental initiator of this disease [ 3]. β-APP is cleaved by β-amyloid precursor protein cleavage enzyme-1 (Balong, along with the digestion by γ-secretase, which results in the release of Aβ [ 4].
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