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Using a standard design procedure, based on analyzing the ecosystem for which the design is applicable, allows for the documentation of responses and allows ecological engineering to be used to test ecological theories.
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Time to response was measured from the date of transplantation to the first documentation of response.
The duration of response was measured from the documentation of response (CR or PR) to PD.
The duration of response was measured from the first documentation of response to disease progression (PD).
Response duration was measured from the first documentation of response to disease progression.
The median time to initial documentation of response was 2 months (range, 2.0 34.0 months).
Whenever possible, patients with evidence of tumour response were to have confirmation within 4 6 weeks after initial documentation of response.
The duration of response was defined as the time from the first documentation of response to disease progression.
All responses were independently reviewed and had to be confirmed ⩾28 days after the initial documentation of response.
All responses were centrally reviewed and had to be confirmed 28 days or more after the initial documentation of response.
All objective responses were confirmed by follow-up computed tomography at least 4 weeks after the initial documentation of response.
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