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Patients who died without documentation of progression were considered to have progressed on the date of their death.
Quantifying the extent of conjunctival fibrosis for documentation of progression in conjunctival scarring disease is a clinical challenge.
PFS was defined as the time from randomization to the day of documentation of progression or death, whichever was earlier.
Assessment of TtPD was determined by measuring the time interval from the beginning of treatment until the first documentation of progression or death due to any cause.
Course of treatment and radiologic documentation of progression was reviewed by the multidisciplinary UW Neuro-Oncology Tumor Board comprised of physicians providing patient care.
Patients who died without documentation of progression were considered to have had tumour progression on the date of death, unless documented evidence indicated that no progression occurred.
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The duration of PR was from the start of treatment until the first documentation of disease progression or death from progression; the duration of a CR was from the time it was first documented.
For cetuximab treatment, PFS was calculated from the date of documented progression after the previous treatment to the next documentation of disease progression or death.
PFS was defined as the time elapsed from the initial blood sampling to the documentation of disease progression (according to RECIST) or, if no progression was observed during the follow-up, to the last follow-up visit.
Freedom from progression (FFP) – time from randomisation to first documentation of disease progression.
For patients with intralesional margins (ILM), the time from primary surgery to clinical/instrumental documentation of local progression of disease was defined as time to local progression.
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