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Also recommended was enhanced use and development of molecular biomarkers for identification of susceptible populations, and documentation of exposures and effects in epidemiologic and toxicologic studies.
As the result, the evidence of the Morinaga dried milk poisoning is severely limited in regard to documentation of exposures or dose levels, and no evidence is at hand to determine dose-response or dose-effect relations of arsenic exposure.
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Although seemingly straightforward, documentation of exposure-response relationships can be difficult.
Three core issues have to be covered: (1) documentation of exposure, (2) monitoring impacts of the specific GMO and (3) large-scale and long term-effect relationships [12].
In this review, we have briefly described the usefulness of certain biomarkers for the documentation of exposure and early biological effects, with special concern for the prediction of cancer.
Documentation of exposure to the top 10 major risk factors of mortality.
If documentation of exposure of a persistent chemical is all that is necessary, then biologic monitoring should be adequate.
The documentation of exposure using biomarkers to confirm parental reports enhances accuracy and precision of the determinants.
Careful study design, well-characterized laboratory methods, and rigorous documentation of exposure status are required to determine the predictive value of such tests.
Study strengths include the unbiased selection of exposed and unexposed groups, medical record documentation of exposure status, and a large sample size.
This would involve continuous monitoring of cause-specific mortality through routine civil registration, regular documentation of exposure to leading risk factors, and monitoring effective coverage of key preventive and curative interventions in the health sector.
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