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Patient selection and management before ONS should comprise confirmation of refractory CM and exclusion of ONS contraindications, detoxification in case MO, patient information about ONS, exclusion of disorders explaining the headache or preventing ONS, and detailed written documentation (modified according to [8]).
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The initial documentation was modified to gain consent from patients for the assessor to contact them by telephone at 3 months and 6 months.
Model documentation following a modified version of the ODD protocol [54] is available in [55].
To identify specific sites in COI that appear to have been under notable amounts of site-specific selection for amino acid replacements, we used the branch-site model (referred to in the PAML documentation as 'the modified Model alsoalso M2a) in PAML v.3.15 [46], [46].
In both the Brighton and Cardiff scores, the documentation charts were modified to better capture the score items and consequently might have influenced treatment decisions (perhaps appropriately), thus increasing apparent score performance [ 27, 28].
Studies have demonstrated knowledge gaps among clinicians in following the publication of guidelines [ 19] though modifying documentation or wording may make them more user-friendly [ 20, 21].
Documentation was performed using a modified version of the WHO observation record.
The documentation techniques provided by the Unified Modeling Language (UML) were modified to achieve a straight forward documentation covering the whole development cycle from the business process model to generator-based computer applications.
Time logs can be developed or modified to assist in documentation.
Surgery documentation will be collected using a modified version of the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS) classification of meniscal tears questionnaire, 34 which is filled out by the operating surgeon.
Documentation and an extensive tutorial (with permission modified from the Perl API) is also available at the GitHub website.
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