Exact(1)
Diseases receive a different level of significance if treatment options are not covered by insurers in general, but could be covered by them were fulfilling certain conditions to be meet, such as like qualified documentation, enrolment in controlled therapeutic studies, etc. as in the case of ASCT [ 63].
Similar(59)
Subsequent to that discussion, if the child's parent agreed, documentation for enrolment in the study would be completed.
We found that 40.7% of the patients had one or more documentation of enrolment after their initial entry into the DMP.
There also might be other reasons for why a doctor submits a new enrolment documentation instead of a follow-up documentation: for example, in the DMP DM 2, until July 2008, a new enrolment form needed to be submitted every time a patient changed to a new doctor, in which case a new enrolment form might have been used even though the patient never interrupted his or her participation in the DMP.
Methodology There was an extensive review of available documentation including budgets, enrolment data and project reports.
As described above, there are two types of documentation forms, one for enrolment in the DMP and one for follow-up.
It is already known 27 28 29 that the presence of certain features of study design such as blinding, formal enrolment, and automated documentation of results can substantially affect reported effect size.
Careful documentation of outpatient attendance, subsequent enrolments and consent interviews will ensure that no patient is "selected" for inclusion or exclusion from the study.
For this reason we decided not to differentiate between enrolment and follow-up documentation forms in this study and defined dropout solely based on the absence of any kind of submitted DMP documentation in 2007.
PFS was defined as the time from study enrolment to the first documentation of progressive disease (PD) or death from any cause.
We investigated the patterns of re-enrolments in more detail and found that in 31.1% (1,561) of the cases, re-enrolment was associated with a change to a new doctor, and in 30.8% (1,547) the patient was missing at least two documentation intervals before the time of re-enrolment, indicating removal from the DMP and later re-enrolment.
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