To get further information and annotation, the KEGG database is queried via the KEGG API for each element in the document (pathway, entries, reactions, relations, substrates, products, etc).
Since all documented pathways of ascorbate biosynthesis require either GULO or GLDH, organisms lacking both of these enzymes are likely to be ascorbate auxotrophs (Chatterjee, 1973).
In the present review we discuss documented pathways that regulate PEDF levels, however, other mechanisms may also participate in the regulation of PEDF expression, function and degradation.
To ensure the accuracy and the consistency of the data, each referenced pathway was cross-checked by different researchers and finally all the documented pathways were checked by one researcher.
Information about eight candidate genes for RAO identified in a family-based whole-genome scan study [ 20] was also imported into IPA® to identify documented pathways linking these candidate genes to the BALF proteins identified with proteomics.
The most well documented pathways involved a class of DREB/CBF transcription factors, which specific binding to the DRE/CRT cis-elements in the promoters of the target genes [ 5, 7].
The difficulty with this approach is the sheer size of the data sets, the large number of documented pathways, and the complex statistics required to determine the significance of findings.
Moreover, FBA can identify the most documented pathway interactions.
Transposon mediated exchange provides a documented pathway for the movement of this gene between insect cells, and two different types of viruses.
embedded subtle errors into the case, reflecting the five main categories of documented pathway errors (insulin, communication, intravenous fluids, nutrition, and discharge delay).
