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c, d X-ray of the docking zone after 9 months.
These results motivated us to inspect the docking zone of Taspase1 in more detail.
When Taspase1 monomers bind to each other, both 'docking heads' bind near the catalytic center of the opposing monomer (docking zone).
Thirdly, a 'docking head' became visible when each monomer was analyzed by its own (Fig. 3C; DH = docking head, DZ = docking zone).
Noteworthy, when the 'docking head' binds to its cognate docking zone in an opposing Taspase1 monomer, the most important amino acids affected by the dimerization process are again R262 and E295 (see below).
This 'dock-and-click' mechanism appears to be a prerequisite for the functional activation of Taspase1, because mutations within the docking head (W173A, L146A/L165A, and L146A/H177A; I160E and C163E) or the corresponding docking zone (R262A, E295A and R299E) abolished the pro- and enzymatic activities of Taspase1.
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The project, renamed Barclays Cycle Hire, will install 6,000 bikes at about 400 docking stations across zone one from 30 July.
We conclude that Syp is required for proper vesicle biogenesis and docking at active zones, and that syp mutants exhibit enlarged AZs and PSDs.
The 2400-km-long 2400-km-long 2400-km-longimandyan Mobile Belt is delimited against the Asian plate by the Indus–Tsangpo Suture, the zone of docking of India with mainland Asia.
The requirement of UNC-13 for SV docking at the active zone has been revealed by ultrastructural analyses of synapses using high pressure freezing fixation (Weimer et al., 2006; Hammarlund et al., 2007).
Some vesicles are docked in the perisynaptic zone beyond the adherens junctions at the far edge of the synapse, sometimes called 'ectopic docking' (Zenisek et al., 2000; Lenzi et al., 2002; Matsui and Jahr, 2003; Hammarlund et al., 2007).
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