The mutation of TRK-T3 tyrosine 291, docking site for both Shc and FRS2, abrogates the oncogene biological activity.
In the first paragraph we have shown that the biological activity of TRK-T3 is abrogated by the mutation of the Tyr291, docking site for Shc and FRS2.
Once PA attaches to the cell, it forms a docking site for two anthrax proteins called lethal factor (LF) and edema factor (EF).
Mechanistically, these structures favor binding to histone cores and can function as a docking site for sliding nucleosomes.
Similar to Grb2 and Shc, phosphorylated SH2B1 and 2 may serve as a docking site for downstream factors.
In contrast, on the β16 side of the portal, there is no conserved, putative docking site for substrate peptides.
We demonstrate that CaMKIV directly phosphorylates Cabin1, a transcriptional corepressor for myocyte enhancer factor 2, creating a docking site for 14-3-3 14-3-3 14-3-3 its nuclear export.
Our results indicate that the zinc finger-rich domain of RanBP2 constitutes a docking site for exportin-1 during nuclear export.
The docking site for each receptor was delineated by a grid box encasing residues at the Elk-1 dimer interface site.
Situated in front of the gene, this switch, called an enhancer, is a docking site for proteins that control the gene's activity.
E203 provides a docking site for the P-6 residue.
