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Currently, the operator intuitively determines docking positions.
These docking positions constituted 42% of all observed docking sites of OT-GKR.
Then we insert lysine K85 next to the major groove of DNA at the dyad axis, as it was found to be in 27 out of 30 top-ranked docking positions [28], and oriented the globular domain so that the residues involved in DNA binding (R42, R47, R73, R74, R94, K40, K69, K85, K97, H 25 and H62) are making close contacts with the entry and exit linkers.
Compounds with the docking positions showing high-energy conformations, such as unreasonable angles and torsions caused by the steric effect, were excluded.
This indicates that the phase space is sufficiently sampled; also we repeated the docking protocol for each compound many times and found that best docking positions and their respective minimum energies are consistently reproduced.
The position of FOG1 was found to be far from other three candidates due to the other three candidates not migrating significantly, but remaining close to the initial docking positions.
Similar(51)
It is shown that mobility of the protein atoms improves docking positioning accuracy.
Cygnus does not dock directly with the ISS but is moved to its docking position by the ISS's robotic arm.
Dependence of the docking positioning accuracy is investigated as a function of parameters of the docking algorithm and the number of protein moveable atoms.
In this paper, we present a method of assisting the URV operator to identify the most appropriate docking position in the context of a desired dexterous workspace.
The HTV does not dock directly with the ISS but approaches to a distance of 10 metres (33 feet) and is moved to its docking position by the ISS's robotic arm.
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