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"do significant things" is correct and usable in written English
You can use it in situations when you want to encourage someone to make important contributions or take meaningful action. For example, you might say, "You have so much potential. Work hard and do significant things with your life!"
Exact(1)
Do significant things for them that help them (like helping them move, finding them a job and getting them hired, or setting them up on a good date) and they'll be ready to help you in return when you ask.
Similar(59)
If the empty signature line is meant to be proof that Trump really didn't know about the agreement, then it would, like his comments on the plane, be evidence that Cohen defrauded Clifford and was in outright violation of legal ethics rules that oblige lawyers to tell their clients when they are doing significant things on their behalf.
What I am trying to say is that a group of kids from small town Indiana who grew up without a lot of worldly benefits nevertheless have done significant things with their lives and have made a contribution to society that is greater than would have necessarily been anticipated.
"We are slowly approaching the end of a period characterised by the style of one man who has done significant things," said Di Montezemolo, 65. "It's a bit of a similar case to what will happen to me: within the decade I will face this question, but when I am 75 not 82".
"Varone has done significant, wonderful things for our hospital," said Roger Acker, the honorary lifetime chairman of the board.
There are so many people who do magnificent, significant things, and I don't.
"I thought he was the most significant public figure doing important things," Mr. Stern said, "and I wanted to be part of it".
People's hopes will be raised that he intends to do some significant things".
"I still think we have a chance to do some significant things," said David Plouffe, his longtime adviser.
"When a comedian tries to do more significant things, very often he strikes out," agrees Mr. Allen, who has himself sometimes seemed lost in half-baked homages to foreign masters.
"People who have mathematical, computational, and statistical skills, [and] establish a collaboration and work on real biological problems, have the chance of doing some very, very significant things for human welfare," he says.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com