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In particular, a considerable portion of the included studies were retrospectively accrued cohorts, which inherently contained greater potential for confounding than do randomised controlled trials.
Do randomised controlled trials have a role in identifying the best empirical management strategies for febrile illness in resource poor settings?
Studies using such databases would not replace the need to do randomised controlled trials but could serve as an important tool to supplement the contributions of trials to evidence based medicine.
The survival benefit of the addition of other drugs to HD-MTX is matter of debate, considering that not only do randomised trials comparing mono-chemotherapy with HD-MTX and poly-chemotherapy not exist, but also that the activity of these drugs has not been assessed as a single drug in prospective trials.
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37 51 Though it has not been possible to conduct a randomised trial of delaying the primary series of DTP vaccinations, we did randomise children at 4.5 months of age to early MV in an attempt to reverse the adverse effect of DTP and we achieved a threefold reduction in mortality.
If we don't randomise, "using phonics" might not be the only difference between the two groups of schools.
Patients and methods We did this randomised, controlled, single-center trial with assessor-blinded outcome assessment in patients admitted to ICU.
While many of these studies have found significant results, they suffer from a combination of subjective self-report measures as the primary outcome, a lack of proper controls, often combine music with some type of relaxation therapy, or do not randomise subjects to control and treatment conditions.
Like our study, they do not randomise.
Women with mild prolapse who received pelvic floor muscle training showed greater improvement in symptoms than did women randomised to a watchful waiting strategy.
3 9 14 15 We did a randomised placebo controlled trial in primary care patients with irritable bowel syndrome to assess the effectiveness of treatment with either psyllium or bran on symptoms and quality of life.
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