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If raised levels of ROS do impair the resistant Rils' photosynthetic capability, this might represent a cost to the plant.
The occurrence of neuropathy and nephropathy in diabetic patients do impair cardiovascular function if hyperglycemia condition is maintained for a prolonged period of time.
In our original manuscript we reported that mutations (R107E/R109E/R115L) in the Norrin GAG binding site do not affect the ability of Norrin to bind Fz4CRD but do impair the activation of signalling.
Our recent behavioral observations in adult BD cats show that 2BD from birth indeed does not weaken motion sensitivity in adulthood, whereas delayed onset 2N2BD, or 4 months BD do impair motion perception (Zapasnik and Burnat 2013).
For example cholinergic MS/VDB lesions do impair latent inhibition (Baxter, Holland, & Gallagher, 1997), conditional learning (Janisiewicz, Jackson, Firoz, & Baxter, 2004), and context-place recognition memory (Easton, Fitchett, Eacott, & Baxter, 2011), so it is not that these lesions are completely without effect.
VS lesions do not cause marked increases in premature responding on the 5-CSRTT (Christakou et al., 2004) but do impair performance on the differential reinforcement of low rates of responding (DRL) task where delays are typically longer and uncued (Pothuizen et al., 2005; Fletcher et al., 2009).
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Manual stimulation did not affect the amount of cortisol released but did impair milk ejection.
HAL did not block the development of tolerance to the locomotor stimulant effects of caffeine, but did impair the recovery from tolerance following withdrawal of caffeine.
It never did impair our functioning.
They found that these mutations did not alter protein expression, but did impair GPCR signaling [8], [32].
For example, Easton, Greene and Srinivas [20] found that although modality changes did not impair priming of 2D patterns or of 3D objects, it did impair performance on an old/new recognition task.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com