This result suggests that ubiquitous production of the Gal80 protein does not cause deleterious effects on zebrafish development and that it can efficiently inhibit the activity of the Gal4 in transgenic zebrafish.
The blood loss caused by the collection of the 15 mL/kg volume and subsequent reinfusion of blood in sheep did not cause deleterious effects on this species.
"I would be loath to do anything deleterious to morale, but then again, I have to look at myself in the mirror every day at the end of the day," he told me.
Never apologize, never explain: the familiar aphorism is usually invoked after the fact, when the apologizing or explaining has been done, to deleterious effect.
Furthermore, essential functions of MADS factors whether in mice or humans, usually do not suffer deleterious mutations in MADS factors and thus natural selection would eliminate such mutations.
High peak pressures do have a deleterious effect on cerebral hemodynamics, however, and can be avoided in this setting [ 7].
The question is how many of these 120 mutational paths are evolutionarily allowed in the sense that they do not involve deleterious intermediate combinations (i.e. combinations involving strongly decreased fitness).
First, we show that the assumption of frequent, slightly deleterious mutations do agree with observations and experiments, on the contrary to the assumption of few, moderately deleterious mutations.
Small population size makes selection against deleterious mutations less effective, but so does linkage between deleterious and adaptive alleles (Hill and Robertson 1966).
However, these weights were designed for the situation when all alleles are deleterious, and do improve the efficiency in those situations (with the exception of step-up, where there is little difference).
In addition, we do not explicitly model deleterious phenotypic mutations.
