Exact(3)
We found that NKp44 was not expressed on dNK, in agreement with one previous report [ 43] but in conflict with others [ 7, 44, 45].
The ligand for CD161, LLT1, is expressed by trophoblast [ 39, 40], suggesting that CD161 may be downregulated by dNK in the presence of its ligand.
In humans, various studies bring evidence for a direct role for dNK in modulating extravillous trophoblast cell differentiation and migration from anchoring villi, which is in part dependent from their potential to deliver IFN- γ [ 58].
Similar(57)
In addition, our results exposed a previously unknown role for the C-terminal regions of these dNKs in determining substrate selectivity.
The aim of this research was to evaluate density of decidual natural killer cells (dNK, CD56+bright) in decidua basalis in patients with placenta accreta.
Similar to dNK and in agreement with previous reports (Table 1), CD56bright eNK are uniformly positive for NKG2D and NKp46, uniformly negative for NKp44, mostly positive for NKG2A and a substantial proportion express KIR [ 35– 35].
Analysis of the various cytokines showed a significantly higher production of angiogenin (P < 0.05; Fig. 1A), soluble interleukin-2 receptor (sIL-2R, P < 0.01; Fig. 1B), endostatin (P < 0.05; Fig. 1C) and PLGF (P < 0.01; Fig. 1D) by high-RI dNK cells in comparison with normal-RI dNK cells.
The unusual KIR repertoire in dNK, which is skewed toward recognizing HLA-C, is not present in eNK.
If, on the other hand, the bias arises in response to trophoblast- or pregnancy-specific factors, it would only be present in dNK, and not eNK cells.
In culture, we were unable to recapitulate the skew toward KIR2D expression observed in dNK, either by treating eNK with soluble factors produced by trophoblast, or with IL-15.
RS, DNK, and JCM participated in experimental design and assisted in editing the manuscript.
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