Sentence examples for dna with lower from inspiring English sources

Although replication protein A (RPA) is sufficient for the recruitment of ATRIP to ssDNA, we show that a distinct ATR-ATRIP complex is able to bind to DNA with lower affinity in the absence of RPA.

These observations suggest that there are at least two in vitro ATR-ATRIP DNA binding complexes, one which binds DNA with high affinity in an RPA-dependent manner and a second, which binds DNA with lower affinity in an RPA-independent manner but which requires an as of yet unidentified protein.

MftR exhibits a two-step melting transition and binds DNA with lower affinity at 37 °C.

It has been shown that these isoforms bind DNA with lower efficiency, thus their transactivation capacity may rely more on protein protein interactions than on DNA-binding specificity (Arce et al. 2006; Weise et al. 2010), allowing the regulation of different sets of genes in different molecular contexts (Mayall et al. 1997; Vadlamudi et al. 2005; Mahmoudi et al. 2010).

The fraction of horse reads recovered after treatment of TP1 and TP2 extracts with DNA phosphatase exhibited G→A cumulative misincorporation rates that were lower than those observed without DNA phosphatase treatment, suggesting that DNA phosphatase allowed preferential access to ancient DNA templates with lower levels of cytosine deamination.

The functional role of chromatin-bound MCMs in DNA replication is derived primarily from embryonic and yeast studies, where MCMs that are not functioning in DNA replication (with lower chromatin affinity) are blocked from entering, or exported out of, the nucleus [4], [41], [42], [43], [44].

On the other hand, DNA fragments with lower GC content are not affected by this problem and can be amplified over their full length.

The (4S -FPro turned out to be a DNA binder with lower specificity; comparable binding was obtained for 3,4S -FProoproline witurnedlanar ring coutormatoon.

The majority of these were in poor quality, low input DNA samples with lower read depth and obvious background sequencing noise (potentially an artefact of PCR from very limiting copies of amplifiable DNA).

Sometimes DNA samples appear degraded into smaller fragments and therefore, the higher molecular-weight STR loci can be scarcely amplified so creating incomplete DNA profiles with lower discrimination power [ 2].

Sometimes forensic samples may contain only small amounts of genomic DNA (less than 100 pg), referred to as LCN DNA (low copy number DNA), and/or may also be degraded into fragments smaller than 100 bp, resulting in failure of amplification of the STR loci and an incomplete DNA profile with lower discriminatory power [ 5].