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More potent inhibitions and smaller IC50 are achieved by duplex DNA with higher curvatures.
A novel junction-probe electrochemical biosensor for the sequence-specific detection of DNA with higher sensitivity and higher discrimination ability was described in here.
Thus, when co-localized, both factors may access the DNA with higher affinity than their individual binding sites alone would allow.
Topoisomerase IIβ, whether full length or C-terminally truncated, gave stronger binding than its topoisomerase IIα counterpart, suggesting topoisomerase IIβ binds DNA with higher affinity, consistent with isoform specific DNA interactions [29] [30].
A search for MeCP2 homologs identified MBD1, MBD2 and MBD4, which all bind methylated DNA with higher affinity than unmethylated DNA, via their conserved MBD homology domain.
When the DNA extraction methods were compared (Table 2), the bead beating method consistently extracted DNA with higher 260/230 and 260/280 ratios.
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Among the five tested conventional methods, bead beater/phenol chloroform based DNA extraction method with STES buffer (BP1 method) gave a yield of DNA with high purity.
In this study, the cancer cells were isolated by LCM yielding low amounts of DNA suitable only for COMPARE-MS, an assay that has been shown to robustly enrich for methylated DNA with high sensitivity and specificity.
A | An incredibly powerful new technology that makes it possible to "cut and paste" DNA with high precision.
GNPs have been used to detect DNA with high sensitivity and selectivity [1].
Different microfluidic device structures can be exploited to separate DNA with high throughput.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com