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The results demonstrated that these TFs interact with methylated DNA with different effects compared with their cognate DNA sequences.
A series of duplex DNA with different intrinsic curvatures have been designed as inhibitors to hTopo I.
By substituting the hairpin DNA with different sequences, this strategy as a new signal transduction approach could be conveniently extended for detection of other short miRNA and DNA.
Herein, silver nanoclusters (Ag NCs) templated by polymer and unmodified gold nanoparticles (Au NPs) are designed as a new colorimetric platform for sensitively differentiating telomere DNA with different lengths, monitoring G-quadruplex and dsDNA.
This suggests that several forms of DNA with different sizes are formed after the ligation step and that the modified protocol led to the reduction of the ligation product patterns.
All remaining probes were produced by polymerase chain reaction (PCR) amplification of D. buzzatii or D. mojavensis genomic DNA with different primer pairs.
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Prior to the study of primary samples, to confirm that the nested PCR we used could accurately reflect the methylation status of genomic DNA, we performed PCR using DNA solutions containing methylated and unmethylated genomic DNAs with different ratios.
These cytoplasmic DNAs are recognized by ASC but not NLRP3, suggesting that the inflammasome components may have the ability to discern disparities among DNAs with different origins.
Four DNAs with different EGFR mutations [two with the common deletions (c.2235_2249del15 and c.2240_2257del18), one with a tandem base mutation (TBM; see Terminology in Methods) and one with a doublet] were amplified with standard primers.
These functional DNAs with different modifications have been developed for sensing, imaging, and therapeutic systems.
Different DNA methyltransferases (DNMTs) ensure proper DNA methylation with different specificity for unmethylated or hemimethylated DNA.
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