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All compounds were characterized by using 1H, 13C NMR, IR, UV Vis and fluorescence spectroscopy, and DNA binding properties of these conjugates to calf thymus DNA were studied by using fluorescence titration, UV titration, isothermal titration calorimetry and CD analysis.
The interactions of these compounds with DNA were studied.
The effects on the electrophoretic mobility of the pUC18 plasmid, the DNA denaturation temperature, and ethidium bromide (EtBr) binding to DNA were studied.
After characterization by spectral and analytical data, the interaction studies of compounds (4 6) with DNA were studied by UV vis, fluorescence spectroscopy, gel electrophoresis and molecular docking.
Circulating pharmacodynamic biomarkers of cell death, full-length and/or cleaved CK18, and oligonucleosomal DNA were studied in the phase 1b trial.
Interaction studies of 1 and 2 with CT DNA were studied by using various biophysical techniques, which showed high binding affinity of 2 with CT DNA.
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The interaction between the compounds and DNA was studied by circular dichroism (CD) method.
PNAs with terminal modifications of varying structure and charge were synthesized and their binding to DNA was studied.
Effect of NiO-NP on genomic DNA was studied through detailed analyses of RAPD profiles which allows detection of even slightest changes in DNA sequence of treated plants.
The charge transport properties of DNA are studied by the first-principle simulation to discuss the possibility of applying DNA to molecular wire.
Binding of the compounds to calf-thymus DNA was studied using UV vis and steady state fluorescence spectroscopy, as well as thermal denaturation.
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