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A possible explanation for these two sequences having only one AT-stretch is that HMGA2 does not necessarily need DNA to interact with because it can bind to DNA- or chromatin binding proteins as well [17], [18].
Realistic models relating complex traits (i.e., phenotypes) to genotypes may exhibit nonlinearity (epistasis), allowing distinct regions of DNA to interact with one another.
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It is generally understood that PM-induced oxidative DNA damage can interfere with the ability of DNA methyltransferase to interact with DNA to reduce methylation [ 38].
For instance, van Oijen et al. used biotin avidin system to fix only one end and allow the rest of the single DNA molecule to interact with exonuclease [3].
The zinc finger protein ZBTB33 (also known as Kaiso) has been shown in vitro to bind preferentially to methylated DNA and to interact with the SMRT/NCoR histone deacetylase complexes.
The capability of G-rich secondary DNA structures to interact with each other using non Watson-Crick base pairing makes it an excellent candidate to coordinate chromosome dynamics such as pairing during meiosis.
To demonstrate the capacity of T-DNA-NR to interact with target cells, we visualized the cellular binding and uptake of Cy3-labeled T-DNA-NRs (T-DNA-NR-Cy3).
Fig. 2C top panel reveals that DNA-PKcs still co-immunoprecipitates AIRE from the cell extracts treated with EtBr or RNaseA, which indicates that AIRE does not require DNA or RNA to interact with DNA-PKcs.
To reveal its information, DNA must be untangled and often distant regions within one molecule or between fellow DNA molecules have to interact.
We found that the protein has the ability to self-assemble in discrete protein nanoparticles resembling viral capsids, to bind and condense plasmid DNA (pDNA), and to interact with eukaryotic cell membranes.
Another method used to build 3D structures, called DNA origami, is tougher to use to build complex shapes, Yin said, because it relies on a long "scaffold" strand of DNA that folds to interact with hundreds of shorter "staple" strands – and each new shape requires a new scaffold routing strategy and hence new staples.
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CEO of Professional Science Editing for Scientists @ prosciediting.com