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1944 Researchers at the Rockefeller Institute prove that genes are made of deoxyribonucleic acid by mixing pneumonia bacteria (pneumococcus) with foreign DNA to induce inheritable traits.
The mechanism of action for platinum-containing anticancer drug utilizes the presence of DNA to induce cancer cell death by apoptosis [30, 31].
Interestingly, AO/EB and Hoechst stained cells observed at IC50 concentration shows that 1 brings about conformational change on DNA to induce apoptosis which would be the basis underlying its cytotoxic property.
CRISPR can be used to make double strand breaks in genomic DNA to induce mutations in specific gene targets, including knockout mutations or more specific gene engineering (knock-in).
The ability of DNA to induce protective correlates of immunity to pathogenic influenza in a primate is an important step forward for this technology.
The ability of DNA to induce potent and cross-reactive immune responses against influenza in primates is of considerable interest and may provide a useful tool to influenza prevention efforts.
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However, possible applications are therapeutic intervention using triplex oligonucleotides with therapeutic isotopes which can be brought near to specific DNA sequences to induce DNA strand breaks at selected loci.
The harder charge modulation makes it more difficult for the DNA targets to induce an electrical signal.
In this report, the use of DNA vaccination to induce class II restricted antigen specific proliferative responses was studied.
This suggests that BRCA1 subverts a conserved RNAPII degradation response to DNA damage to induce lethality in yeast.
Chemotherapy agents that damage DNA appear to induce senescence to a much greater extent than agents that target microtubules [37].
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