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The anticancer effect of cisplatin mainly depends on its DNA-damaging activity, via its direct interaction with DNA to form DNA adducts [ 27].
PAHs bind covalently to DNA to form DNA adducts which are the indicator of DNA damage and are considered to be human mutagens and carcinogens [ 5].
Previously, the team designed DNA to form helices bundled by cross-linked staple strands in a honeycomb-like lattice.
Multiple proteins are assembled on centromeric DNA to form the kinetochore structure.
Consequently, we further mixed SAP10, polyethylenimine (PEI) and DNA to form the ternary nanocomplexes for gene delivery investigation.
Nanoscale vectors comprised of cationic polymers that condense DNA to form nanocomplexes are promising options for gene transfer.
Kinetochores are large structures composed of hundreds of proteins that assemble onto centromeric DNA to form a microtubule-binding site that is essential for proper chromosomal segregation.
Reactive oxygen and nitrogen radicals produced during metabolic processes, such as respiration and inflammation, combine with DNA to form many lesions primarily at guanine sites.
In the presence of the target DNA, the hairpin-probe hybridizes with the target DNA to form double-stranded structure with a blunt 3′-terminus.
We have synthesized a PEG conjugate of PEI that complexes DNA to form small, stable colloids with a steric polymer coat on their surface.
The key to getting the DNA to form this way, and to holding it in place, are short "staples" of DNA with sequences chosen to attach to specific parts of the long strand.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com