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Because of PCR amplification bias, the genetic identification of a DNA that contributes trace amounts to a mixed sample represents a tremendous challenge.
Co-immunoprecipitation experiments suggest that WRN and RPA association is enhanced in response to fork blockage inducing-treatments and this interaction is instrumental for the WRN-mediated displacement of RPA from DNA that contributes to fork recovery [ 23].
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What they found were three areas of DNA that contributed to determining tunnel length, and one area affecting whether or not the crossbred mice dug an escape tunnel.
Cancer is a disease arising from both genetic and epigenetic modifications of DNA that contribute to changes in gene expression in the cell.
These multiple genetic variants of small effect are called quantitative trait loci (QTLs), referring to the loci in the DNA that contribute to the variation in continuously (quantitatively) distributed traits.
Theoretically, independent mutations can happen by a common mechanism on the same type of DNA module that contributes to different genes or genes' regulatory elements.
So far, several groups have identified human genes and regions of mitochondrial DNA that might contribute a bit to longevity, for instance by protecting against cardiovascular disease and Alzheimer's.
In recent work, E6 and E7 over-expression has been shown to induce replicative stress in primary keratinocytes suggesting that potent loss of growth control through E7-mediated Rb antagonism drives uncontrolled origin firing leading to damaged DNA that may contribute to cervical cancer pathogenesis (Bester et al, 2011).
Previous analyses of the HPRT mutational spectrum [ 38– 45] had revealed structural features in DNA that probably contribute to mutation induction at the HPRT locus, for example, missense mutations due to single base substitutions leading to amino acid substitutions; nonsense point mutations leading to premature stop codons and truncated proteins; deletions leading to the loss of enzyme activity.
The program then used 70 different predictive features for each DNA change, such as the DNA sequence and structure of the resulting protein, to identify any of the distinguishing characteristics of driver mutations those DNA changes that contribute to cancer compared with other genetic changes.
So the team set out to identify DNA variants that contributed to humans' rounded brains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com