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Similarly, in mammalian cells, the shelterin complex is composed of TIN2, TRF1, TRF2, TPP1, POT1, and RAP1, which provide higher-order DNA structures, the T-loop of which might participate in telomere protection [ 146, 149, 150].
The double-stranded DNA strand displacement algebras perform computations as a result of the interactions between single and double-stranded DNA structures: the single-stranded structures act as signals that are processed by double-stranded structures that act as gates.
The discovery that genetic expansions of (CTG)· CAG) repeated DNA sequences are the mutagenic cause of 14 progressive diseases, including Huntington's disease and myotonic dystrophy, stimulated renewed interest in the formation and repair of slipped-strand DNA structures, the supposed mutagenic intermediates of repeat tract mutations.
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They are characterized by the presence of an unusually dense disc-like mitochondrial DNA structure, the kinetoplast, which is located at the basis of flagellum's attachment the site to the cell body.
In the binary one-nucleotide gapped DNA structure, the 5′-phosphate in the gap is hydrogen bonded to Lys35 and Lys68.
As compared to the starting A- and B-DNA structures, the average rmsd values were 3.6 and 2.1 Å, respectively.
Therefore, the function of RHAU unwinding the G4 DNA structures on the regulatory region of gene is essential for spermatogonia differentiation and meiosis initiation.
Here, we confirmed that the generated DNA structures from the microsponge system were very long polymeric structures, which correspond to the number of ODN repeating units.
The used DNA structures of the PDB database: a and b 2M2C; c—1XRW.
The used DNA structures of the PDB database: a and b 2M2C; c—1XRW; and d 2MIW.
The used DNA structures of the PDB database: a, b 2M2C, c 1XRW, and d 2MIW.
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