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Taking a cue from viruses that attach to cells to infect them, Bathe hopes to design a variety of DNA structures that deliver payloads of antibodies or even gene-editing enzymes such as Cas9 to diseased cells within the body.
G-quadruplexes (G4) are one of the several different forms of non-canonical DNA structures that can occur in our genome.
By constructing strands of DNA whose sequences of bases along their length are precisely known, Shih and his lab have been able to design 3-D DNA structures that effectively build themselves like automated Lego blocks, and whose properties can be tuned down to the nanoscale.
Telomeres, repetitive DNA structures that protect the ends of eukaryotic chromosomes, shorten with age.
In addition it remains possible, that further HBoV sequences were not amplified due to secondary DNA structures that cannot be resolved by PCR protocols.
This assay detects only HIV-1 DNA structures that have undergone both single stranded DNA template switches, including both unintegrated and integrated linear viral genomes.
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"The iconic DNA structure that so many know and love and that we now see in many logos has to open up," said Nogales, who is a Howard Hughes Medical Institute HHMIinvestigatortor as well as a senior faculty scientist at the Lawrence Berkeley National Laboratory.
So the life form itself isn't completely 100% artificial, per se, but since its genetic makeup is based on an artificially created DNA structure that controls the cell, it can be categorized as man-made since DNA is the building block from which all life is created and maintained.
G-quadruplex or G4 DNA is a unique form of four-stranded non-B DNA structure that engages certain G-rich sequences, presence of such motifs has been noted within telomeres.
Cisplatin adducts induce bulky alterations in the DNA structure that disturb DNA replication, leading to cell-cycle arrest and apoptosis.
The Holliday junction is a four-way DNA structure that is the central intermediate in homologous recombination.
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