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Poly(ADP-ribose) polymerase-1 (PARP-1) is a sensor for DNA strand breaks and some unusual DNA structures and catalyzes poly(ADP-ribosyl)ation of nuclear proteins with NAD+ serving as substrate.
As was found for segmental duplications, also MSRs may be unstable DNA structures and therefore contain certain sequences that can function as a hotspot of structural genomic rearrangements.
"We came up with the idea of dropping biochemical nanomachine switching completely in favor of the interactions between DNA structures and electric fields," said Simmel in a TUM news release.
It is required for meiotic recombination, double-strand break repair, processing of mis-folded DNA structures and maintaining telomere length.
Ultrasensitive determination of the chiral nature of a molecule is important for fully understanding protein and DNA structures, and for the design, synthesis and purification of drug molecules.
CdS has a great potential for usage in photochemical catalysis, solar cells, nonlinear optical materials, various luminescent devices, probes for exploring DNA structures, and fluorescent probes for peptide detection [4].
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In addition to its ability to modulate DNA repair activities, TRF2 also has direct effects on DNA structure and topology.
Different structural scales capture different aspects of the DNA structure, and this could partly explain any variation in performance.
This information is essential to understand sequence effects on DNA structure and has implications on diverse problems in the structural biology of DNA.
This predictable behaviour made type II restriction enzymes valuable tools in the study of DNA structure and in recombinant DNA technology.
Subsequently we removed the whole protein, DNA structure and water molecules that were not in the QM region.
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