Sentence examples for dna structure we from inspiring English sources

Based on the protecting effect of folate receptor (FR) toward folic acid (FA) modified DNA and the signal amplification of supersandwich DNA structure, we designed an interesting electrochemical biosensor for FR.

We have demonstrated that by using such clamp-switch probe that binds a target through two distinct and sequential events, which leads to the formation of a triplex DNA structure, we can improve both the affinity and specificity of recognition compared to a classic Watson Crick hybridization probe.

Because negative supercoils can help stabilize many non-B DNA structures, we wanted to be able to directly compare the products of transcription from relaxed, linear templates and negatively supercoiled templates.

To probe the nature of the unusual DNA structures further, we took cross-sections through them and compared the profiles to those of 'normal' DNA.

However, these ideas must be regarded as speculative, since at present it is not possible to determine whether or not the abnormal DNA structures that we describe exist in vivo.

To account for the inhibitory effect of the supercoiled DNA structure on qPCR amplification, we have taken steps to ensure an accurate measurement by disrupting the supercoiled mtDNA conformation with a preheating step prior to qPCR analysis.

To define the DNA structure required for kinase activation, we synthesized a series of DNA molecules and tested their interactions with purified DNA-PK CS).

In this study, we evaluated DNA structure in terms of various physicochemical and conformational properties.

Importantly, in response to DNA damage, the p53 protein is stabilised by phosphorylation events involving the DNA structure checkpoint kinase, CHK2, which we show is not active in shTBX2 cells treated with cisplatin.

Our genome-wide search yielded complete retroelements and "cut-and-paste" DNA transposons, whose structure we characterized in detail.

DOI: http://dx.doi.org/10.7554/eLife.03197.012 To further understand how PhuZ participates in development and centering of the infection nucleoid and to determine the composition of the DNA in this structure, we followed infection nucleoid formation via fluorescence in situ hybridization (FISH).