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The condensation of such a probe, in the case of a prospective anticancer drug, depends significantly on the superhelicity of the plasmid, thus showing, additionally, the role of the three-dimensional DNA structure on the formation of the DNA-compound complex.
While much is known about DNA structure on the basepair level, this scale represents only a fraction of the structural levels involved in folding the genomic material.
Effects of DNA structure on the AZP-modified DNA TSV responses are discussed.
Results indicate that the developed logic system based on the different protective capacities of DNA structure on gold nanoparticles provides a new pathway for the design of the combinatorial logic operation in one system and presents a useful strategy for development of advanced sensors, which may have potential applications in multiplex chemical analysis and molecular-scale computer design.
In the presence of DNA2-antibody2 (and) and methylene blue (MB -labeled DNA1-Ab1 probes, the addition of target protein could induce the sandwich iMB -labeledon among two probes and the protein to trigger the hybridization of DNA1 and DNA2, which subsequently unfolded the hairprobesA theform additionarm DNA structure of targetnsing interface.
Hence, the influence of DNA structure on sumoylation efficiency could serve as an elegant mechanism to limit PARP-1 sumoylation to the appropriate locations.
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The cytotoxic effect of imidazotriazole 7 was noticed on DNA structure of breast cancer cell line (T47D) by using the comet assay.
The binding of these TFs to DNA might be dependent on the DNA structure of the whole TFBS.
Taken together, there are two authentic G4 DNA structures on the promoters of mouse c-kit genes.
Our results further confirmed that c-kit had two G4 DNA structures on the promoters of c-kit in vivo.
Therefore, the function of RHAU unwinding the G4 DNA structures on the regulatory region of gene is essential for spermatogonia differentiation and meiosis initiation.
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