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Our work may provide a new concept for designing an SWNT-induced DNA nanomachine and for the detection of i-motif DNA structure at pH 7.0.
Ag+ can fold a C-rich single stranded DNA sequence into i-motif DNA structure at neutral pH and that folding is reversible by chelation with cysteine (Cys).
The smallest units of DNA that contain sequence information are the 16 dinucleotides and characterizations of DNA structure at this level have yielded important insights into the factors which affect the conformational properties of DNA and its packaging into nucleosomes.
High concentrations of minor groove-binding drugs such as distamycin, which are known to alter DNA structure at high concentrations [24], abolished CbfA binding to the C-module in vitro [7].
The helicase CHD1 probably regulates frq transcription by modulating DNA structure at the frq locus.
This research indicates that Cu2+ can be used to alter the conformation i-motif DNA structure at room temperature and acidic pH into a hairpin-type structure.
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This mechanism then affords a spatiotemporal window for Topo II and other DNA repair enzymes to access and resolve catenated or other aberrant DNA structures at the midpoint of these threads.
Telomeres are protective DNA structures at the ends of chromosomes that have been likened to the tips of shoelaces.
Q: Has it been intimidating, exciting, or both, to be working on DNA structures at the Cavendish Laboratory, given the history of what it means to DNA.
Tim was also required for the recruitment of Plk1 to centromeric DNA and formation of catenated DNA structures at human centromere alpha satellite repeats.
It has also been reported in S. cerevisiae that Rad53 (Cds1 homolog) is required to prevent accumulation of unusual DNA structures at the replication fork in response to fork arrest induced by HU or MMS [14], [16], [17].
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