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Therefore, cells with overall disruption of higher-order DNA structure are irreversibly committed to functional failure in the short term.
DNA-metal and DNA-metal based complexes interactions and their effect on DNA structure are already known [ 22– 29].
One can speculate that 3′ to 5′ exonuclease and endonuclease activity associated with MRE11 is dispensable for tissue survival, but proteins RAD50 and RAD51 supporting DNA structure are not.
Initially and before curation, the "Object types" referring to the DNA structure are labeled with the " g" code when referring to the locus, the " t" code when referring to the nucleic acid coding sequence of the transcript and the " p" code when referring to the amino acid sequence of the protein.
The minor effects of (2 S)- N-HB-dA adducts on DNA structure are in contrast with the more pronounced distortions induced by the bis-alkylation products at N-dA induced by diepoxybutane (DEB): N, N- 2,3-dihydroxybutan-1,4-diyl -2′-deoxyadenosine (N- 2,3-dihydroxybutan-1,4-diyl -2′-deoxyadenosine
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"The DNA structure is one of those turning points," he says.
The first Watson-Crick attempt to build a model of the DNA structure was a disaster.
Therefore, the DNA structure is ideal for electron transfer due to hopping mechanism.
G-quadruplex DNA structure is considered to be a very attractive target for antitumor drug design due to its unique role in maintaining telomerase activities.
It is demonstrated that long-range coherent charge transport along the DNA structure is supported by mobile polaron and breather solutions, suggesting that DNA seems suitable for the design of functional nanostructures as ingredients in molecular nanoelectronic devices.
In the presence of monovalent Na+ ions, we find that the stretch modulus (γ1) of the paranemic crossover and its topoisomer JX DNA structure is significantly higher (∼30%) compared to normal B-DNA of the same sequence and length.
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