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Ghosh, A. et al. Indolicidin targets duplex DNA: structural and mechanistic insight through a combination of spectroscopy and microscopy.
Replication is associated with DNA structural and topological changes as well as with specific post-translational modifications of DNA damage response factors that assist DDT and replication completion (Branzei & Foiani, 2010).
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Subsequent gel electrophoresis and DNA sequencing analyzed the DNA structural changes and found certain modifications in the DNA forms.
In this review we aim to give an overview of the terminology and key aspects of these DNA structural properties, and illustrate their potential added value compared to relying solely on the nucleotide sequence in genomics studies.
The resulting adduct formation can impair the functions of enzymes, DNA, structural proteins, and other macromolecules, thereby leading to the inhibition of cellular processes and eventual cytotoxicity.
We have made the first attempt to use low-energy ions in plasma immersion ion implantation and deposition (PIII-D) to bombard naked plasmid DNA to investigate effect on the DNA structural modification and mutation.
Covalent or non-covalent interactions with DNA are the basis for many potential biomedical applications of copper complexes, ranging from DNA structural probes and footprinting agents to anticancer drugs to gene delivery.
Methylation of promoter CpG islands leads to DNA structural changes and, consequentially, gene inactivation [ 5].
This finding has the consequence that pyrimidines most likely have a "compensatory" role, which is consistent with DNA structural constraints, and a wobble base at the first anti-codon position.
During evolution, some of the chromosomal rearrangements that arise during speciation are almost certain to share themes with those discussed here, including breakage at sites of DNA structural variation and joining by NHEJ.
Evaluation on in vitro data of twenty mouse transcription factors shows that our method outperforms a method based on simple-instance learning with DNA structural properties, and the widely used k-mer counting method, for nineteen out of twenty of the transcription factors.
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