Sentence examples for dna specificity of from inspiring English sources

When compared with specific detection of Bartonella DNA, specificity of the 16S rDNA PCR was 100% but sensitivity was low (49.8%, 122 of 245 lymph nodes were positive).

The high DNA specificity of homing endonucleases makes them a powerful protein scaffold to engineer enzymes for genome manipulation.

In this chapter, we present a simple and powerful method to either know the DNA specificity of a wild-type protein or design new specificities by using the protein design algorithm FoldX.

Advances in changing target DNA specificity of Cre recombinase [7], [8], [9], [10], Flp recombinases [11], [12], [13], [14] and recently λ Int [15] create an opportunity to develop genome engineering tools based on tailor-made variants of tyrosine recombinases.

For example, the DNA specificity of Hox HDs is known to be modified by interactions with co-factors such as the PBC and MEIS subclasses of TALE HD proteins (Moens and Selleri, 2006; Mann et al., 2009).

The mammalian zinc finger proteins Sp1 and Sp3 bind to this motif (and other similar motifs) [ 46, 47], but the DNA specificity of the GC-box binding zinc finger proteins (to which Mig1, Mig2, Sp1 and Sp3 belong) is determined by amino acid residue 18 in each finger [ 15], and there is no reason to expect that Mig1 or Mig2 would bind to this motif.

The basis for the altered DNA specificities of two Cre recombinase variants, obtained by mutation and selection, was revealed by their cocrystal structures.

However, anti-DNA specificity of at least some B cells in 3H9 mice transgenic for the heavy chain of an anti-DNA antibody [ 100] suggests that exposure to self-DNA may not always result in clonal deletion, and that some DNA-specific clones may escape tolerance.

The large variety of circulating HIV-1 strains and, accordingly, integrated proviruses was addressed by the programmable DNA-specificity of TALEs.

Rees, H.A. et al. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.

Now: NSERC postdoctoral scientist, University of British Columbia Dave studied the evolution of DNA specificity in steroid receptors.